ICN (31/07/2010)
Theres a couple of settings in Guru that you might want to change in Options on the front of the GUI.
1. Enable Tool Tips. Found in the Misc Tab. This will give you a value onscreen of how much you are adjusting things.
2. Sequencer Retardation. Found in the Audio Tab. If you find the 1st beat of Guru is not hitting correctly when you hit play in your sequencer, try a setting of 100ticks.
Dont forget to put a line of 16th's in it & f*** around with the groove. 
Its on 10% Dirty Swing by default.. scroll down that menu & you'll find Swing Thing.. 40 - 50% is setting that sounds minimal.
You can drag & drop the pattern from the "pattern buttons" onto your arrange.
When you do, hit Guru onto an empty pattern button or stick the Mode to "Gate" rather than "Sync".. so that it doesnt play double or flam. You'll know when you hear it! 
In the "Pad Edit" Tab.. you can do all your ASDR stuff, Pan, FX, Reverse etc.. You can also Layer up to 8 sounds on each Pad. Good for all sorts of stuff!!
The "Graphs" Tabs lets you draw in glitchy repeats and change pitch.. so you could do a bassline in it no probs.
Loading samples into it - you can load "Kits" onto all the Pads on the bottom left hand screen.. But to get a one shot on a pad, you'll need to go into "Pads".
Finally, if you do make a tune you like etc.. make sure to hit "save as" on the front of the GUI & save the Guru settings & samples into your project folder.. and hit save if you make any additions / changes.
Guru only links to the files.. so if you dont save the files into your project folders & you move the samples or they get lost.. you're in trouble. I found that out when I was updating my computers OS.. 