OK, just tried with the first preset Factory/Bass Electro/Basic velo electric fizz loading the AU version of ANA v1.5 first, it started to work fine while playing that D2 midi note loop like you. Stopped it & try several times and after a while it's started making the noise. Loading the VST version of ANA v1.5 just gave the same result with noise.
Changing the Quality or Increasing the Buffer Size in Live's preferences / Audio did not help, still this noise.
- Saved Project, closed Live, reopened it : Still the same noise.
Hmmm, weird stuff...
Edit : Got a Win 10 Pro x64 with Live 10 & ANA v1.5 so I'll have to try on Windows as well, to see if it helps troubleshooting between Live 10 or MacOS or ANA ?? I'm gonna do that now & let you know in next post, should take a few minutes.