Is this happening when you reach a certain number of ANA 2 instances in your Studio One session ( meaning 2,3,4 instances is OK but problem starts to happen when loading more instances ) ??
What's the CPU load and your samples rate settings in Studio One when this happens ?
Seems you're running the latest plug-in version with Studio One 4 Up to date and quite a powerful PC, so not sure what could be the issue here.
Could you please try a full clean uninstall ( using something like free IO Bit Uninstaller on WIN i.e ) and a clean new install to make sure the .dll or some files haven' been corrupted or something like this ? That would help for troubleshooting in the case that the issue is still happening after a clean new installation of ANA 2 and needs to be investigate further by support.
Make sure to back up your user presets if any if using IO Bit uninstaller.
Thanks, waiting for your update then