Is this happening on every preset or just specific ones ?
It would be great if you could narrow it down to one instance of ANA 2 only and troubleshoot if it's preset related or not. For example do you have the same problem when using the "Init preset" ?
If you find that it's preset related, then could you please upload the preset here, I could test on my end but that won't be using Reaper though.
Any insight @phil_johnston ? User is probably on v2.0.94 since it's the Slate edition.