Hello there,
I have had the most use and fun with ANA 2 far beyond any soft synth plugin I have ever used! But there is strange behavior afoot:
Since 2.5.3, a few sounds (that I have found so far) have missing Wavetable and or Sampler data. They are blank, and silence ensues.
Also, is there a way to point the load preset function to the preset folder? I can show preset folder to find where they are, in a hidden folder, but load preset goes to the desktop and I must navigate each time, so with these two maladies, my previously enjoyed sound surfing has slowed to a frustrating crawl.
Any advice would be appreciated. I balk at uninstall/reinstall for time constraints, but alas, if I must…
I labeled a track in my session “Digital Fantasy,” which means I liked the sound enough to memorialize the patch name in said session, but now it is silent; See ANA 2 screenshot below.
Hi there and welcome to the forums ! 
This “Digital Fantasy” preset is from the Slate Digital Expansion Pack “ANA 2 Ultra Multisample”.
You’re likely missing files in your installation, so head up to the Slate Digital Installer Page and scroll down the page to retrieve the ANA 2 Expansion Packs downloads.
Download the pack and run the installer. While you’re at it, I suggest you’ll download them all and reinstall all packs, there’s updates for Presets Packs as well from time to time 
You’ll need your Slate Digital “All Access Pass” credentials to download.
This Preset is only using a SAW in main OSC 2, OSC 1 & 3 are empty but it’s using multi-samples and that’s what’s missing in your install.
You need to switch to Multi-Sample Edit mode to see all samples when you’re using a Multisample Preset.
To see samples install location, you can click on the Sample Name in the Sampler OSC slot on top and then click the Folders/Detailed view icon in the sample Browser.
But, yeah, try to reinstall the Expansions Packs, should solve this issue
Cheers
