Crackle Issue


I have Alesis M1 Active mk2 speakers running through an Audiophile 2496 soundcard.

I’m running Cubase SX and the problem is i am experiencing crackle with my tune, i thought it might have been the bass distorting but i turn it off and i still have crackle, the crackle seems to effect every part i have.

I however can render down the track and play the .wav back via winamp/media player and there is no crackle.

Does anyone have any idea what i could do to resolve this issue?